has characteristic has characteristic has material basis in germline mutation in FREM2 hereditary disease isolated cryptophthalmia https://www.malacards.org/card/cryptophthalmos_unilateral_or_bilateral_isolated nonsyndromic cryptophthalmia GARD:0016797 UMLS:C1852453 ankyloblepharon, simple MESH:C565138 cryptophthalmos, unilateral or bilateral, isolated SCTID:718691008 cryptophthalmos with microphthalmia and Peters anomaly Isolated cryptophtalmia is a congenital abnormality in which the eyelids are absent and skin covers the ocular bulb, which is often microphthalmic. Six cases of complete bilateral crytophthalmia have been described. Transmission is autosomal dominant. MEDGEN:342242 OMIM:123570 MONDO:0007410 Orphanet:91396 DOID:0111717 cryptophthalmia has an isolated presentation