congenital unilateral hypoplasia of depressor anguli oris https://github.com/monarch-initiative/mondo/issues/4069 https://www.malacards.org/card/cayler_cardiofacial_syndrome https://www.malacards.org/card/congenital_unilateral_hypoplasia_of_depressor_anguli_oris UMLS:C0431406 MEDGEN:140911 SCTID:51409009 Congenital unilateral hypoplasia of depressor anguli oris is a congenital anomaly, characterized by the unilateral hypoplasia/agenesis of the depressor anguli oris muscle, resulting in an asymmetric crying facies in neonatal period/ infancy (drooping of one corner of the mouth during crying) while eye closure, nasolabial fold and forehead wrinkling are symmetric. While it can be isolated, this anomaly is also seen in 22q11.2 deletion syndrome and can be accompanied by other major congenital anomalies of the cardiovascular system, as well as less frequently the musculoskeletal, cervicofacial, respiratory, genitourinary, and, rarely, endocrine systems. When isolated, the condition is cosmetically insignificant as the infant gets older (as the muscle does not contribute significantly to facial expression in childhood/ adulthood). ICD9:759.89 GARD:0016557 MONDO:0007443 Editor note: TODO check relationship to 22q11.2 deletion syndrome Orphanet:1166 isolated asymmetric crying facies OMIM:125520 22q11.2 deletion syndrome