has material basis in germline mutation in EFEMP1 retinal drusen Doyne honeycomb retinal dystrophy https://rarediseases.info.nih.gov/diseases/1912/doyne-honeycomb-retinal-dystrophy https://www.malacards.org/card/doyne_honeycomb_retinal_dystrophy https://www.malacards.org/card/familial_drusen Malattia leventinese dominant drusen MEDGEN:321900 DHRD DOID:0060745 dominant radial drusen Doyne honeycomb retinal dystrophy Orphanet:75376 GARD:0001912 OMIM:126600 SCTID:193411004 MONDO:0007471 Doyne honeycomb retinal dystrophy (DHRD) is a condition that affects the eyes and causes vision loss. It is characterized bysmall, round, white spots known as drusen that accumulate beneath the retinal pigment epithelium(the pigmented layer of the retina). Over time, drusen may grow and come together, creating a honeycomb pattern. It usually begins in early to mid adulthood, but the age of onset varies.The degree of vision loss also varies. DHRD is usually caused by mutations in the EFEMP1 gene and is inherited in an autosomal dominant manner. UMLS:C1832174 DHD Doyne honeycomb degeneration of retina familial flecked retinopathy