has material basis in germline mutation in disease has location CFH retinal dystrophies primarily involving Bruch's membrane retinal drusen basal laminar drusen https://www.malacards.org/card/basal_laminar_drusen basal laminar drusen DOID:0060746 A retinal drusen characterized by yellow-white deposits (drusen) that accumulate beneath the retinal pigment epithelium on Bruch membrane and that has material basis in mutations in the CFH gene on chromosome 1q31.3. OMIM:126700 GARD:0015060 UMLS:C0730295 MONDO:0007472 MEDGEN:152676 drusen of Bruch membrane MESH:C563034 Bruch's membrane