has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of disease has feature GJB6 gap junction channel activity Diffuse palmoplantar hyperkeratosis Clouston syndrome https://www.malacards.org/card/clouston_syndrome MONDO:0007510 SCTID:54209007 alopecia, dysplastic nails, palmar and plantar hyperkeratosis UMLS:C0162361 autosomal dominant hidrotic ectodermal dysplasia palmoplantar hyperkeratosis and alopecia Clouston syndrome (or hidrotic ectodermal dysplasia) is characterized by the clinical triad of nail dystrophy, alopecia, and palmoplantar hyperkeratosis. Clouston syndrome Orphanet:189 GARD:0002056 Patel Bixler syndrome OMIM:129500 MEDGEN:56416 hidrotic ectodermal dysplasia, autosomal dominant DOID:14693 ED2 ectodermal dysplasia, hidrotic, 2 hidrotic ectodermal dysplasia ectodermal dysplasia, hidrotic diffuse palmoplantar keratoderma ectodermal dysplasia syndrome