has material basis in germline mutation in ACVR1 hereditary disease skeletal system disorder fibrodysplasia ossificans progressiva https://github.com/monarch-initiative/mondo/issues/4948 https://github.com/monarch-initiative/mondo/issues/6751 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/fibrodysplasia_ossificans_progressiva MedDRA:10068715 Stone man syndrome FOP DOID:13374 progressive myositis ossificans OMIM:135100 UMLS:C0016037 fop NCIT:C3040 MEDGEN:4698 Orphanet:337 ICD9:728.11 NORD:1143 NANDO:1200871 GARD:0006445 icd11.foundation:2102976705 SCTID:82725007 ICD10CM:M61.1 MONDO:0007606 fibrodysplasia ossificans progressiva Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites. NANDO:2201020 Stone Man syndrome obsolete primary bone dysplasia with progressive ossification of skin, skeletal muscle, fascia, tendons and ligaments subcutaneous tissue disorder