has material basis in germline mutation in LMBR1 laurin-Sandrow syndrome https://github.com/monarch-initiative/mondo/issues/4948 https://rarediseases.info.nih.gov/diseases/155/laurin-sandrow-syndrome https://www.malacards.org/card/laurin_sandrow_syndrome mirror-Image polydactyly DOID:0111350 mirror hands and feet with nasal defects laurin-Sandrow syndrome fibula and ulna, Duplication of, with absence of tibia and radius fibula ulna duplication tibia radius absence MESH:C535689 SCTID:715440003 mirror hands and feets-nasal defects syndrome tetramelic mirror-Image polydactyly Laurin-Sandrow syndrome (LSS) is characterized by complete polysyndactyly of the hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella), often associated with ulnar and/or fibular duplication (and sometimes tibial agenesis). It has been described in less than 20 cases. Some cases with the same clinical signs but without nasal defects have also been reported, and may represent the same entity. The etiology of LSS is unknown. Different modes of inheritance have been suggested. Orphanet:2378 Sandrow syndrome MEDGEN:340697 UMLS:C1851100 LSS MONDO:0007615 laurin Sandrow syndrome laurin-Sandrow syndrome, segmental icd11.foundation:671594481 OMIM:135750 GARD:0000155 congenital limb malformation polydactyly-syndactyly-triphalangism