has material basis in germline mutation in ALX3 frontorhiny https://github.com/monarch-initiative/mondo/issues/4948 https://www.malacards.org/card/frontonasal_dysplasia_1 NCIT:C129028 Orphanet:391474 frontorhiny frontonasal malformation isolated median cleft face syndrome frontonasal dysplasia frontonasal dysplasia 1 Frontorhiny is a distinct syndromic type of frontonasal malformation characterized by hypertelorism, wide nasal bridge, broad columella, widened philtrum, widely separated narrow nares, poor development of nasal tip, midline notch of the upper alveolus, columella base swellings and a low hairline. Additional features reported in some include upper eyelid ptosis and midline dermoid cysts of craniofacial structures and philtral pits or rugose folding behind the ears. An autosomal recessive inheritance has been proposed. OMIM:136760 GARD:0012642 MONDO:0007636 frontonasal dysplasia type 1 isolated median cleft syndrome median Facial cleft syndrome MEDGEN:1803615 ALX3-related frontonasal dysplasia FND1 UMLS:C5574965 DOID:0081045 frontonasal dysplasia