disease has basis in disruption of disease caused by disruption of disease has feature aromatase activity reproductive system disorder aromatase excess syndrome https://rarediseases.info.nih.gov/diseases/12494/aromatase-excess-syndrome https://www.malacards.org/card/aromatase_excess_syndrome ICD9:259.8 familial hyperestrogenism AEXS UMLS:C1970109 MEDGEN:409989 gynecomastia, familial, due to increased aromatase activity SCTID:709075008 hereditary prepubertal gynecomastia increased aromatase activity GARD:0012494 DOID:0090122 aromatase excess syndrome icd11.foundation:191989744 MESH:C000591739 MONDO:0007690 OMIM:139300 Aromatase excess syndrome is a rare, genetic endocrine disease characterized by increased levels of estrogen due to elevated extraglandular aromatase activity. Males present with heterosexual precocious puberty which manifests with pre- or peripubertal onset of gynecomastia, premature growth spurt, accelerated bone maturation resulting in decreased adult stature, and may present mild hypogonadotropic hypogonadism. Female patients may have isosexual precocious puberty or not have any manifestations at all. gynecomastia, hereditary Orphanet:178345 aromatase activity, increased peripheral precocious puberty obsolete anomaly of puberty or/and menstrual cycle of genetic origin precocious puberty in female inborn errors of metabolism