has material basis in germline mutation in TBX5 autosomal dominant disease Holt-Oram syndrome https://github.com/monarch-initiative/mondo/issues/4948 https://www.malacards.org/card/holt_oram_syndrome Holt Oram Syndrome atriodigital dysplasia atrio-digital syndrome HOS 1 icd11.foundation:1169240278 Holt-Oram syndrome (HOS) is the most common form of heart-hand syndrome and is characterized by skeletal abnormalities of the upper limbs and mild-to-severe congenital cardiac defects. DOID:0060468 Holt-Oram syndrome SCTID:19092004 heart-hand syndrome, type 1 MEDGEN:120524 MESH:C535326 UMLS:C0265264 Orphanet:392 ICD9:759.89 heart-hand syndrome NORD:1248 atriodigital dysplasia type 1 ventriculo-radial syndrome atrio digital syndrome MONDO:0007732 GARD:0006666 HOLT-Oram syndrome NCIT:C125592 HOS heart-hand syndrome type 1 MedDRA:10050469 Cardiac-limb syndrome OMIM:142900 multiple congenital anomalies/dysmorphic syndrome without intellectual disability heart-hand syndrome non-syndromic limb reduction defect cardiogenetic disease