autosomal dominant disease hyperkeratosis-hyperpigmentation syndrome https://www.malacards.org/card/hyperkeratosis_hyperpigmentation_syndrome Orphanet:1336 UMLS:C1840428 MEDGEN:326735 Hyperkeratosis-hyperpigmentation syndrome describes a very rare hyperpigmentation of the skin characterized by tiny hyperpigmented spots mainly on skin exposed to sunlight, together with mild punctate palmoplantar papular hyperkeratosis as a major feature. There have been no further descriptions in the literature since 1993. MONDO:0007757 GARD:0016563 OMIM:144190 hyperkeratosis-hyperpigmentation syndrome MESH:C564172 hyperpigmentation of the skin hereditary skin disorder