has material basis in germline mutation in THRB hyperthyroidism selective pituitary resistance to thyroid hormone https://github.com/monarch-initiative/mondo/issues/7693 https://www.malacards.org/card/thyroid_hormone_resistance_selective_pituitary DOID:0111374 Orphanet:165994 UMLS:C1840364 MESH:C564154 icd11.foundation:482664523 PRTH OMIM:145650 MONDO:0007784 thyroid hormone resistance, selective pituitary Pituitary resistance to thyroid hormone is a rare, genetic thyroid disease, due to reduced pituitary gland responsiveness to thyroid hormone, characterized by mild to moderate hyperthyroidism in association with elevated circulating thyroid hormone levels, normal or elevated thyroid stimulating hormone, and no abnormalities of the pituitary gland on MRI. Patients present with diffuse large goiter, tachycardia, atrial fibrillation, weight loss and/or heat intolerance/perspiration, but no exophthalmos or anterior tibial mixedema. MEDGEN:333543 GARD:0024576 resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta