keratolytic winter erythema https://rarediseases.info.nih.gov/diseases/8275/keratolytic-winter-erythema https://www.malacards.org/card/keratolytic_winter_erythema OMIM:148370 Erythrokeratolysis hiemalis Oudtshoorn disease icd11.foundation:1491245207 keratolytic winter erythema UMLS:C0406756 Erythrokeratolysis hiemalis ichthyosis Orphanet:50943 NORD:1286 ICD9:695.89 Oudtshoorn skin disease KWE Keratolytic winter erythema is a rare epidermal disease, characterized by recurrent centrifugal palmoplantar peeling and erythema presenting seasonal variation (cold weather). Skin lesions may spread to the dorsum of hands and feet and to the interdigital spaces. Lower legs, knees and thighs may also be involved. Episodes may be preceded by itch and hyperhidrosis. Skin biopsy reveals an epidermal spongiosis with clefting in the stratum corneum, followed by regrowth. Keratolytic winter erythema follows an autosomal dominant mode of transmission. SCTID:239064000 MESH:C536155 Oudtshoorn skin keratolytic WINTER erythema MONDO:0007854 MEDGEN:98359 GARD:0008275 epidermal disease