hereditary disease Kyrle disease https://github.com/monarch-initiative/mondo/issues/9097 https://rarediseases.info.nih.gov/diseases/9738/kyrle-disease https://www.malacards.org/card/kyrle_disease hyperkeratosis follicularis et parafollicularis in cutem penetrans MONDO:0007869 Kyrle disease is rare condition that affects the skin. People with this condition generally develop large papules with central keratin (a protein found in the skin, hair and nails) plugs throughout their body. These lesions are typically not painful but may cause severe itching. Although it can affect both men and women throughout life, the average age of onset is 30 years. The cause of the disease is currently unknown; however, it is often associated with certain conditions such as diabetes mellitus, kidney disease, liver abnormalities, and congestive heart failure. In some families, the condition appears to be inherited but an underlying genetic cause has not been identified. Treatment aims to address the associated signs and symptoms and any additional disease that may be present. Lesions often heal spontaneously but new ones continue to develop. UMLS:C0263382 MESH:C538130 MEDGEN:75516 Kyrle disease SCTID:34042008 OMIM:149500 Kyrle's disease ICD10CM:L87.0