has material basis in germline mutation in HSPB8 neuronopathy, distal hereditary motor, type 2A https://www.malacards.org/card/neuronopathy_distal_hereditary_motor_autosomal_dominant_2 Any neuronopathy, distal hereditary motor in which the cause of the disease is a mutation in the HSPB8 gene. The presenting symptoms are paresis of the extensor muscles of the big toe and later of the extensor muscles of the feet and chronic neurogenic alterations in electromyography. GARD:0018262 OMIM:158590 DOID:0111208 MEDGEN:322471 neuronopathy, distal hereditary motor, type IIA HSPB8 neuronopathy, distal hereditary motor MESH:C563561 MONDO:0008025 neuronopathy, distal hereditary motor caused by mutation in HSPB8 HMN2A UMLS:C1834692 distal hereditary motor neuropathy type 2