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    <!-- http://purl.obolibrary.org/obo/MONDO_0008090 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0008090">
        <rdfs:label>cyclic neutropenia</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MONDO_0015134"/>
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        <ns3:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/10437</ns3:IAO_0000233>
        <ns3:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/4521</ns3:IAO_0000233>
        <ns3:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/9097</ns3:IAO_0000233>
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        <oboInOwl:hasDbXref>MEDGEN:65121</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>UMLS:C0221023</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>cyclic agranulocytosis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>NANDO:1200354</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIT:C3820</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DOID:5339</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>cyclic hematopoiesis</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000115>A hematologic disorder caused by a mutation in the ELANE (ELA2) gene, characterized by regular 21-day cyclic fluctuations in the number of blood neutrophils, monocytes, eosinophils, lymphocytes, platelets, and reticulocytes. The recurrent severe neutropenia causes patients to experience periodic symptoms of fever, malaise, mucosal ulcers, and, rarely, life-threatening infections.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>MedDRA:10053176</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>SCTID:191347008</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NANDO:2200746</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD9:288.02</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GARD:0006229</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OMIM:162800</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>dysplasia, myelocytic periodic</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>CN</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>ICD10CM:D70.4</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:C536227</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Orphanet:2686</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>CH</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>neutropenia cyclic</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>periodic neutropenia</oboInOwl:hasExactSynonym>
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    <!-- http://purl.obolibrary.org/obo/MONDO_0015134 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0015134">
        <rdfs:label>constitutional neutropenia</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/MONDO_1060165 -->

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        <rdfs:label>ELANE-related neutropenia</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/MONDO_1060264 -->

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        <rdfs:label>severe chronic neutropenia</rdfs:label>
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