has material basis in germline mutation in LBR autosomal dominant disease leukocyte disorder Pelger-Huet anomaly https://www.malacards.org/card/pelger_huet_anomaly SCTID:85559002 EFO:1001093 MEDGEN:10617 UMLS:C0030779 GARD:0009148 OMIM:169400 icd11.foundation:1210390183 Pelger-Huet nuclear anomaly MESH:D010381 PHA ovoid neutrophil nuclei, developmental delay, epilepsy and skeletal abnormalities DOID:9631 MedDRA:10029377 An autosomal dominant inherited condition caused by mutations in the lamin B receptor gene. It is characterized by defects in the neutrophil lobulation, resulting in the presence of dumbbell-shaped neutrophils with bilobed nuclei in the peripheral blood smear. MONDO:0008214 Pelger Huet anomaly Pelger-Huet anomaly NCIT:C85002 laminopathy