has material basis in germline mutation in ITM2B cerebral amyloid angiopathy ABri amyloidosis https://rarediseases.info.nih.gov/diseases/8344/dementia-familial-british https://www.malacards.org/card/cerebral_amyloid_angiopathy_itm2b_related_1 cerebral amyloid angiopathy, ITM2B-RELATED, 1 cerebral amyloid angiopathy, ITM2B-related, type 1 icd11.foundation:1037669378 MEDGEN:1677186 icd11.foundation:1314005795 ABri amyloidosis FBD dementia familial British Bri amyloidosis MONDO:0008306 dementia, familial British DOID:0070029 OMIM:176500 A cerebral amyloid angiopathy characterized by onset in the 4th to 6th decade of life, progressive mental deterioration, spasticity, muscular rigidity but no tremors, spontaneous movements or sensory changes that has material basis in an autosomal dominant mutation of ITM2B on chromosome 13q14.2. UMLS:C5190835 ITM2B-related cerebral amyloid angiopathy 1 familial dementia, British type MESH:C538208 GARD:0008344 cerebral amyloid angiopathy, British type Orphanet:97345 presenile dementia with spastic ataxia ITM2B amyloidosis