has material basis in germline mutation in LMNA syndromic disease autosomal recessive disease Hutchinson-Gilford progeria syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/4948 https://github.com/monarch-initiative/mondo/issues/5537 https://rarediseases.info.nih.gov/diseases/7467/progeria https://www.malacards.org/card/hutchinson_gilford_progeria_syndrome NANDO:2200833 Hutchinson-Gilford disease Orphanet:740 MONDO:0008310 GARD:0007467 OMIM:176670 Editor note: check whether subset prototype_pattern is appropriate UMLS:C0033300 NCIT:C34951 HGPS premature senility syndrome NANDO:1201007 progeria NORD:1257 MedDRA:10036794 DOID:3911 SCTID:238870004 MEDGEN:46123 Hutchinson Gilford progeria syndrome Hutchinson-Gilford progeria Hutchinson-Gilford progeria syndrome is a rare, fatal, autosomal dominant and premature aging disease, beginning in childhood and characterized by growth reduction, failure to thrive, a typical facial appearance (prominent forehead, protuberant eyes, thin nose with a beaked tip, thin lips, micrognathia and protruding ears) and distinct dermatologic features (generalized alopecia, aged-looking skin, sclerotic and dimpled skin over the abdomen and extremities, prominent cutaneous vasculature, dyspigmentation, nail hypoplasia and loss of subcutaneous fat). Hutchinson-Gilford progeria syndrome ICD9:259.8 progeroid syndrome primary osteolysis laminopathy