has material basis in germline mutation in AKT1 Proteus syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/4948 https://github.com/monarch-initiative/mondo/issues/6751 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/proteus_syndrome proteus syndrome, somatic Proteus syndrome (PS) is a very rare and complex hamartomatous overgrowth disorder characterized by progressive overgrowth of the skeleton, skin, adipose, and central nervous systems. icd11.foundation:760267333 Proteus syndrome OMIM:176920 Elattoproteus syndrome ICD9:759.89 partial gigantism-nevi-hemihypertrophy-macrocephaly syndrome MONDO:0008318 NCIT:C85032 DOID:13482 Orphanet:744 NORD:1622 partial gigantism of hands and feet, nevi, hemihypertrophy, macrocephaly MEDGEN:39008 Wiedemann's syndrome UMLS:C0085261 GARD:0007475 MESH:D016715 gigantism, partial, of hands and feet, nevi, hemihypertrophy, and macrocephaly hemihypertrophy and macrocephaly SCTID:23150001 obsolete syndrome or malformation associated with head and neck malformations PTEN hamartoma tumor syndrome skeletal dysplasia overgrowth syndrome