disease has location disease arises from structure disease arises from alteration in structure retinal cell cancer retinoblastoma https://github.com/monarch-initiative/mondo/issues/2760#issuecomment-894549526 https://www.malacards.org/card/retinoblastoma NCIT:C7541 retinoblastoma, malignant MESH:D012175 A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. MONDO:0008380 Orphanet:790 retinoblastoma UMLS:C0035335 NANDO:2200042 MEDGEN:20552 eye cancer, retinoblastoma ONCOTREE:RBL SCTID:370967009 DOID:768 MedDRA:10038916 RB RB1 ICDO:9510/3 GARD:0007563 icd11.foundation:1855353671 obsolete hereditary eye tumor obsolete inherited vitreous-retinal disease retinal neural layer presumptive neural retina