disease has feature Reduced bone mineral density Singleton-Merten dysplasia https://github.com/monarch-initiative/mondo/issues/6878 https://github.com/monarch-initiative/mondo/issues/7365 https://www.malacards.org/card/singleton_merten_dysplasia syndrome of widened medullary cavities of the metacarpals and phalanges, aortic calcification and abnormal dentition Merten-Singleton syndrome ICD9:733.29 widened medullary cavities of bone, aortic calcification, abnormal dentition, and muscular weakness GARD:0000122 Singleton Merten syndrome SCTID:254114000 SGMRT1 MESH:C537343 UMLS:C0432254 MEDGEN:98481 Singleton-Merten syndrome Orphanet:85191 OMIMPS:182250 MONDO:0008429 SM syndrome singleton Merten syndrome NORD:1718 icd11.foundation:1084593684 Singleton-Merten dysplasia is characterized by dental dysplasia, progressive calcification of the thoracic aorta with stenosis, osteoporosis and expansion of the marrow cavities in hand bones. Additional features included generalized muscle weakness and atrophy, and chronic psoriasiform skin eruptions. It has been reported in four unrelated patients (male and female) and in a family with multiple affected members (male). obsolete primary bone dysplasia with decreased bone density hereditary disorder of connective tissue type 1 interferonopathy of childhood