spastic paraplegia-neuropathy-poikiloderma syndrome https://www.malacards.org/card/spastic_paraplegia_with_neuropathy_and_poikiloderma Spastic paraplegia-neuropathy-poikiloderma syndrome is a complex form of hereditary spastic paraplegia characterized by spastic paraplegia, demyelinating peripheral sensorimotor neuropathy, poikiloderma (manifesting with loss of eyebrows and eyelashes in childhood in addition to delicate, smooth, and wasted skin) and distal amyotrophy (presenting after puberty). There have been no further descriptions in the literature since 1992. Antinolo-Nieto-Borrego syndrome MEDGEN:355814 MONDO:0008442 spastic paraplegia neuropathy poikiloderma familial spastic paraplegia with neuropathy and poikiloderma UMLS:C1866851 Orphanet:2821 OMIM:182815 GARD:0004921 MESH:C536870 autosomal dominant complex spastic paraplegia