disease has feature precocious puberty spastic paraplegia-precocious puberty syndrome https://www.malacards.org/card/spastic_paraplegia_with_precocious_puberty MESH:C536874 familial spastic paraplegia, mental retardation, and precocious puberty Orphanet:2826 OMIM:182820 familial spastic paraplegia, intellectual disability, and precocious puberty MONDO:0008443 MEDGEN:401096 UMLS:C1866850 GARD:0004918 Spastic paraplegia-precocious puberty syndrome is characterized by precocious puberty (due to Leydig cell hyperplasia), progressive spastic paraplegia and intellectual deficit. It has been described in two brothers. The fact that other family members displayed brisk reflexes and dysarthria suggested autosomal dominant inheritance with variable expression. autosomal dominant complex spastic paraplegia