has material basis in germline mutation in F5 coagulation protein disease thrombophilia due to activated protein C resistance https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/thrombophilia_due_to_activated_protein_c_resistance resistance, APC UMLS:C1861171 SCTID:421527008 A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. ICD9:289.81 thrombophilia 2 due to activated protein C resistance DOID:0111902 GARD:0024631 MONDO:0008560 APC resistance thrombophilia due to activated protein C resistance OMIM:188055 MESH:D020016 MEDGEN:396074 THPH2 inherited thrombophilia