has material basis in germline mutation in disease has feature DLX3 Increased bone mineral density tricho-dento-osseous syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/4948 https://github.com/monarch-initiative/mondo/issues/6751 https://rarediseases.info.nih.gov/diseases/7799/tricho-dento-osseous-syndrome https://www.malacards.org/card/trichodentoosseous_syndrome icd11.foundation:131993435 TRICHODENTOOSSEOUS syndrome ICD9:759.89 GARD:0007799 TDO syndrome 1 MEDGEN:78555 SCTID:38993008 TDO syndrome Orphanet:3352 MONDO:0008592 Tricho Dento Osseous Syndrome OMIM:190320 NORD:1786 UMLS:C0265333 DOID:0111565 MESH:C536549 Tricho-dento-osseous dysplasia (TDO) belongs to the ectodermal dysplasias and is characterized by curly/kinky hair at birth, enamel hypoplasia with discolouration and molar taurodontism, increased overall bone mineral density (BMD) and increased thickness of the cortical bones of the skull. kinky or curly hair, dolichocephaly, enamel hypoplasia, increased dental caries, radial dense bones, and brittle nails Tricho-dento-osseous syndrome 1 enamel hypoplasia and hypocalcification with associated strikingly curly hair TDO skeletal dysplasia ectodermal dysplasia syndrome obsolete primary bone dysplasia with increased bone density