has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of ACADM medium-chain fatty acyl-CoA dehydrogenase activity hereditary disease medium chain acyl-CoA dehydrogenase deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/acyl_coa_dehydrogenase_medium_chain_deficiency_of_2 DOID:0080153 medium-chain acyl-Coenzyme A dehydrogenase deficiency acyl-CoA dehydrogenase, medium-chain, deficiency OF SCTID:128596003 medium chain acyl-CoA dehydrogenase deficiency acyl-CoA dehydrogenase, medium-chain deficiency ACADM deficiency medium chain acyl CoA dehydrogenase deficiency ICD9:277.85 MCADD icd11.foundation:627734797 NANDO:2200513 MONDO:0008721 UMLS:C0220710 ACADMD Medium chain acyl-CoA dehydrogenase (MCAD) deficiency (MCADD) is an inborn error of mitochondrial fatty acid oxidation characterized by a rapidly progressive metabolic crisis, often presenting as hypoketotic hypoglycemia, lethargy, vomiting, seizures and coma, which can be fatal in the absence of emergency medical intervention. Orphanet:42 acyl-CoA dehydrogenase medium chain deficiency of MESH:C536038 MCAD deficiency medium chain acyl-coenzyme A dehydrogenase deficiency MEDGEN:65086 GARD:0000540 NCIT:C84538 MCAD Carnitine deficiency secondary to medium-chain acyl-CoA dehydrogenase deficiency ICD10CM:E71.311 OMIM:201450 Acyl-CoA dehydrogenase, medium chain, deficiency of medium-chain acyl-CoA dehydrogenase deficiency acyl-CoA dehydrogenase deficiency