Chiari malformation Chiari malformation type II https://www.malacards.org/card/chiari_malformation_type_ii MEDGEN:108222 Arnold-Chiari malformation type 2 UMLS:C0555206 Arnold Chiari malformation type II GARD:0009232 Chiari type II malformation Chiari malformation type II MONDO:0008816 Chiari malformation type 2 Orphanet:1136 Arnold-Chiari malformation type II is a rare, central nervous system malformation characterized by caudal displacement of the cerebellum, pons, medulla and fourth ventricle through the foramen magnum into the spinal canal, and is typically associated with myelomeningocele. Variable other central nervous system abnormalities might be present (partial or complete agenesis of the corpus callosum, a small fourth ventricle, obstructive hydrocephalus, falx and tentorium defects, and polygyria). Symptoms include hypotonia, apnea with cyanosis, dysphagia, opisthotonus, nystagmus, spasticity, ataxia, and occipital headache. SCTID:373587001 Arnold-Chiari malformation type II OMIM:207950 MedDRA:10056945 spina bifida cystica hereditary neurological disease