disease has location cranial nerve palsy brain disorder palsy progressive bulbar palsy https://github.com/monarch-initiative/mondo/issues/127 https://rarediseases.info.nih.gov/diseases/10928/progressive-bulbar-palsy https://www.malacards.org/card/progressive_bulbar_palsy DOID:681 UMLS:C0030442 icd11.foundation:1143049440 SCTID:54304004 Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. Signs and symptoms of progressive bulbar palsy include difficulty swallowing, weak jaw and facial muscles, progressive loss of speech, and weakening of the tongue. Additional symptoms include less prominent weakness in the arms and legs, and outbursts of laughing or crying (called emotional lability). Progressive bulbar palsy is considered a variant form of amyotrophic lateral sclerosis (ALS). Many people with progressive bulbar palsy later develop ALS. While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms. Fazio-Londe disease progressive bulbar atrophy NCIT:C85026 bulbar palsy, progressive, of childhood EFO:0003783 MEDGEN:18290 MESH:D010244 MONDO:0008890 ICD9:335.22 GARD:0010928 ICD10CM:G12.22 riboflavin transporter deficiency brainstem