disease has feature Lymphedema Cirrhosis Cholestasis syndromic disease liver disorder Aagenaes syndrome https://rarediseases.info.nih.gov/diseases/370/aagenaes-syndrome https://www.malacards.org/card/cholestasis_lymphedema_syndrome Orphanet:1414 LCS1 GARD:0000370 cholestasis-lymphedema syndrome OMIM:214900 DOID:6691 ICD9:576.8 lymphedema-cholestasis syndrome MONDO:0008966 LCS UMLS:C0268314 SCTID:28724005 MESH:C535330 lymphedema cholestasis syndrome Cholestasis-lymphedema syndrome is a rare genetic disorder characterized by neonatal intrahepatic cholestasis, often lessening and becoming intermittent with age, and severe chronic lymphedema which mainly affects the lower limbs. Patients often present with fat malabsorption leading to failure to thrive, fat soluble vitamin deficiency with bleeding, rickets, and neuropathy. In 25% of cases, cirrhosis occurs during childhood or later in life. Chls NCIT:C35709 MEDGEN:78658 cholestasis lymphedema syndrome Aagenaes syndrome primary lymphedema