has material basis in germline mutation in ESCO2 hereditary disease Juberg-Hayward syndrome https://rarediseases.info.nih.gov/diseases/3060/juberg-hayward-syndrome https://www.malacards.org/card/juberg_hayward_syndrome MONDO:0008992 Juberg-Hayward syndrome is a polymalformative syndrome that associates multiple skeletal anomalies with microcephaly, facial dysmorphism, urogenital anomalies and intellectual deficit. NORD:1531 MESH:C537690 MEDGEN:162906 JHS cleft lip/palate-abnormal thumbs-microcephaly syndrome OMIM:216100 icd11.foundation:395922030 GARD:0003060 Orocraniodigital Syndrome UMLS:C0796099 Orphanet:2319 Juberg-Hayward syndrome SCTID:721874001 cleft LIP/palate with abnormal thumbs and microcephaly Orocraniodigital syndrome multiple congenital anomalies/dysmorphic syndrome without intellectual disability