has material basis in germline mutation in C2 classic complement early component deficiency complement deficiency complement component 2 deficiency https://rarediseases.info.nih.gov/diseases/1452/complement-component-2-deficiency https://www.malacards.org/card/complement_component_2_deficiency DOID:0060295 NCIT:C119992 UMLS:C0398756 C2 complement deficiency Complement component 2 deficiency (C2D) is a genetic condition that affects the immune system. Signs and symptoms include recurrent bacterial infections and risk for a variety of autoimmune conditions. Infections can be very serious and are common in early life. They become less frequent during the teen and adult years. The most frequent autoimmune conditions associated with C2D are lupus (10-20%) and vasculitis. C2D is caused by mutations in the C2 gene and is inherited in an autosomal recessive fashion. MEDGEN:585060 complement component 2 deficiency GARD:0001452 complement deficiency caused by mutation in C2 MONDO:0009006 NANDO:2200781 C2D OMIM:217000 immunodeficiency due to a classical component pathway complement deficiency