has material basis in germline mutation in HRAS autosomal dominant disease syndromic intellectual disability Costello syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/5588 https://github.com/monarch-initiative/mondo/issues/5682 https://rarediseases.info.nih.gov/diseases/1550/costello-syndrome https://www.malacards.org/card/costello_syndrome faciocutaneoskeletal syndrome MONDO:0009026 NANDO:2200971 MESH:D056685 NANDO:1200463 congenital myopathy with excess of muscle spindles UMLS:C0587248 SCTID:309776008 CSTLO OMIM:218040 GARD:0001550 NORD:1011 MedDRA:10067380 NCIT:C84652 Orphanet:3071 FCS syndrome Costello syndrome ICD9:799.89 DOID:0050469 MEDGEN:108454 Costello syndrome (CS) is a rare multisystemic disorder characterized by failure to thrive, short stature, developmental delay or intellectual disability, joint laxity, soft skin, and distinctive facial features. Cardiac and neurological involvement is common and there is an increased lifetime risk of certain tumors. icd11.foundation:1946512039 multiple congenital anomalies/dysmorphic syndrome-intellectual disability obsolete dermis elastic tissue disorder Noonan syndrome and Noonan-related syndrome