has material basis in germline mutation in LHX3 non-acquired combined pituitary hormone deficiency with spine abnormalities https://www.malacards.org/card/pituitary_hormone_deficiency_combined_3_2 Orphanet:231720 Winkelmann-Bethge-Pfeiffer syndrome pituitary hormone deficiency, combined, 3 DOID:0061021 UMLS:C3489787 MESH:C536710 Non-acquired combined pituitary hormone deficiency-sensorineural hearing loss-spine abnormalities syndrome is a rare, genetic, non-acquired, combined pituitary hormone deficiency disorder characterized by panhypopituitarism (with or without ACTH deficiency) associated with spine abnormalities, including frequent rigid cervical spine and short neck with limited rotation, and variable degrees of sensorineural hearing loss. The anterior pituitary gland is usually abnormal (typically hypoplastic) and rarely a mild developmental delay or intellectual disability may be associated. OMIM:221750 pituitary hormone deficiency, combined, type 3 CPHD3 non-acquired combined pituitary hormone deficiency-deafness-rigid cervical spine syndrome Deafness, sensorineural with pituitary dwarfism MEDGEN:483740 MONDO:0009091 non-acquired combined pituitary hormone deficiency with spine abnormalities GARD:0010603 Pituitary hormone deficiency, combined with rigid cervical spine combined pituitary hormone deficiencies, genetic form non-acquired combined pituitary hormone deficiency