skin disorder congenital lethal erythroderma https://rarediseases.info.nih.gov/diseases/2192/erythroderma-lethal-congenital https://www.malacards.org/card/erythroderma_lethal_congenital_2 OMIM:227090 MONDO:0009198 congenital exfoliative erythroderma resistant to treatment erythroderma lethal congenital MEDGEN:384008 MESH:C535513 SCTID:722391005 Orphanet:1954 GARD:0002192 A rare skin disorder characterized by erythrodermic, peeling skin from birth with no obvious nail or hair-shaft abnormalities and other associated anomalies including diarrhea, failure to thrive and severe hypoalbuminaemia resistant to correction by enteral or intravenous supplementation. An autosomal recessive mode of inheritance is highly probable. The prognosis is poor and infants die in the first months of life. There have been no further descriptions in the literature since 1992. lethal congenital erythroderma UMLS:C1856898