has material basis in germline mutation in AAAS syndromic disease autosomal recessive disease triple-A syndrome https://rarediseases.info.nih.gov/diseases/457/triple-a-syndrome https://www.malacards.org/card/achalasia_addisonianism_alacrima_syndrome quaternary A syndrome Addisonian-achalasia syndrome glucocorticoid deficiency and achalasia Addisonian achalasia syndrome NCIT:C131005 4A syndrome alacrima-achalasia-adrenal insufficiency neurologic disorder triple A syndrome MONDO:0009279 Double A syndrome ACTH-resistant adrenal insufficiency, achalasia and alacrima adrenal insufficiency-achalasia-alacrima syndrome GARD:0000457 Orphanet:869 OMIM:231550 hypoadrenalism with achalasia AAA NANDO:1200410 MESH:C536008 SCTID:45414006 ICD9:255.41 Allgrove syndrome achalasia addisonianism alacrimia syndrome achalasia-addisonianism-alacrima syndrome DOID:0050602 2A syndrome Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration. UMLS:C0271742 AAAS triple-a syndrome MEDGEN:82889 achalasia alacrima syndrome achalasia-alacrima syndrome AAA syndrome alacrima-achalasia-addisonianism 3A syndrome chronic primary adrenal insufficiency