disease has feature Glomerulonephritis Autoimmunity autoimmune disease anti-glomerular basement membrane disease https://rarediseases.info.nih.gov/diseases/2551/goodpasture-syndrome https://www.malacards.org/card/goodpasture_syndrome MEDGEN:140788 OMIM:233450 pulmonary renal syndrome Orphanet:375 GARD:0002551 An autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis. Some use the term 'Goodpasture syndrome' for the findings of glomerulonephritis and pulmonary hemorrhage and the term 'Goodpasture disease' for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies. Currently, the preferred term for both conditions is “ anti-GBM antibody disease ”. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage). Symptoms may include general body discomfort or pain, bleeding from the nose and/or blood in the urine, respiratory problems, anemia, chest pain, and kidney failure. Anti-GBM disease is thought to result from an environmental insult (smoking, infections, exposure to certain drugs) in a person with genetic susceptibility, such as a specific human leukocyte antigen (HLA) type. Diagnosis is confirmed with the presence of anti-GBM antibody in the blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide. icd11.foundation:591736785 anti-glomerular basement membrane antibody disease EFO:0007290 MedDRA:10018620 ICD9:446.21 anti-glomerular basement membrane disease glomerulonephritis - pulmonary haemorrhage NORD:1198 rapidly progressive glomerulonephritis with pulmonary hemorrhage Goodpasture Syndrome anti-GBM syndrome Goodpasture syndrome NCIT:C84566 UMLS:C0403529 NANDO:1200718 NANDO:1200717 MESH:D019867 rapidly progressive glomerulonephritis with pulmonary haemorrhage NANDO:2200125 glomerulonephritis - pulmonary hemorrhage SCTID:236432001 MONDO:0009303 DOID:9808 obsolete predominantly small-vessel vasculitis obsolete secondary interstitial lung disease in childhood and adulthood associated with a systemic disease obsolete secondary glomerular disease