disease has basis in disruption of disease caused by disruption of L-ascorbic acid biosynthetic process scurvy https://github.com/monarch-initiative/mondo/issues/4684 https://rarediseases.info.nih.gov/diseases/10406/scurvy https://www.malacards.org/card/hypoascorbemia SCTID:76169001 vitamin C deficiency ICD10CM:E54 UMLS:C0036474 EFO:1001169 MedDRA:10039768 deficiency of vitamin C MONDO:0009412 DOID:13724 MEDGEN:20684 A condition that develops in people who do not consume an adequate amount of vitamin C in their diet. Although scurvy is relatively rare in the United States, it continues to be a problem in malnourished populations around the world (such as impoverished, underdeveloped third world countries). Early features of the condition include general weakness, fatigue and aching limbs. If left untreated, more serious problems can develop such as anemia, gum disease, and skin hemorrhages. Symptoms generally develop after at least 3 months of severe or total vitamin C deficiency. Scurvy can be cured with vitamin C supplements taken by mouth. Once recovery is complete, dietary modifications to ensure the 'recommended daily intake' of vitamin C is reached will prevent relapse. Except in the case of severe dental disease, permanent damage from scurvy does not usually occur. An argument can be made that Vitamin C deficiency is a genetic disease shared by all humans, due to our loss of the GULO gene. See OMIM for discussion. Here we choose not to treat as genetic. icd11.foundation:708602629 scorbutus ICD9:267 MESH:D001206 scurvy NCIT:C35010 MESH:D012614 DOID:13577 MedDRA:10047623 vitamin C, inability to synthesise OMIM:240400 ascorbic acid deficiency vitamin deficiency disorder carbohydrate metabolism disease disorder of organic acid metabolism