has material basis in germline mutation in B2M hypoproteinemia, hypercatabolic https://www.malacards.org/card/immunodeficiency_43 hypoproteinemia, hypercatabolic IMD43 immunodeficiency 43 UMLS:C1855796 Beta-2-microglobulin deficiency MONDO:0009434 OMIM:241600 GARD:0015185 MEDGEN:343422 DOID:0111981 B2M deficiency MESH:C565476 MHC class I deficiency immunodeficiency disease