periodontal disorder autosomal recessive disease Papillon-Lefevre disease https://www.malacards.org/card/papillon_lefevre_syndrome Orphanet:678 MONDO:0009490 palmoplantar keratoderma with periodontosis UMLS:C0030360 NORD:1552 MEDGEN:45306 DOID:3389 keratosis palmoplantaris with periodontopathia GARD:0003100 PALS keratosis palmoplantar - periodontopathy ICD9:759.89 Keratoris palmoplantaris with periodontopathia PAPILLON-Lefevre syndrome Papillon-LEFèvre syndrome MESH:D010214 Papillon Lefèvre Syndrome OMIM:245000 SCTID:40158001 PLS NCIT:C84992 keratosis palmoplantar-periodontopathy syndrome palmar-plantar hyperkeratosis and concomitant periodontal destruction Papillon-Lefevre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis. Pls hyperkeratosis palmoplantaris with periodontosis functional neutrophil defect diffuse palmoplantar keratoderma disorder of lysosomal-related organelles CTSC-related disorder