has material basis in germline mutation in SLURP1 mal de Meleda https://github.com/monarch-initiative/mondo/issues/6749 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/mal_de_meleda keratosis palmoplantaris transgrediens of Siemens keratosis palmoplantaris transgradiens of Siemens UMLS:C0025221 Orphanet:87503 MONDO:0009552 DOID:0060862 ICD9:757.39 MDM SCTID:239069005 Meleda Disease NORD:1428 MEDGEN:7522 icd11.foundation:1850911834 Mal de Melada (MdM) is a diffuse palmoplantar keratoderma initially reported from of the Island of Meleda characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgradiens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema. GARD:0000092 OMIM:248300 Meleda disease mal de Meleda diffuse palmoplantar keratoderma