has material basis in germline mutation in MAT1A methionine adenosyltransferase deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/methionine_adenosyltransferase_i_iii_deficiency MEDGEN:75700 isolated persistent hypermethioninemia Orphanet:168598 Hypermethioninemia due to methionine adenosyltransferase deficiency is a very rare metabolic disorder resulting in isolated hepatic hypermethioninemia that is usually benign due to partial inactivation of enzyme activity. Rarely patients have been found to have an odd odor or neurological disorders such as brain demyelination. methionine adenosyltransferase deficiency MAT I/III deficiency methionine adenosyltransferase deficiency, autosomal recessive MAT deficiency GARD:0008397 hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency OMIM:250850 UMLS:C0268621 NCIT:C123435 brain demyelination due to methionine adenosyltransferase deficiency MONDO:0009607 inborn disorder of methionine cycle and sulfur amino acid metabolism