has material basis in germline mutation in RBBP8 hereditary disease Jawad syndrome https://www.malacards.org/card/jawad_syndrome Orphanet:313795 JWDS Kelly syndrome GARD:0017410 JAWAD syndrome Jawad syndrome is a rare, genetic, multiple congenital anomalies/dysmorphic syndrome characterized by congenital microcephaly with facial dysmorphism (sloping forehead, prominent nose, mild retrognathia), moderate to severe, non-progressive intellectual disability and symmetrical digital malformations of variable degree, including brachydactyly of the fifth fingers with single flexion crease, clinodactyly, syndactyly, polydactyly and hallux valgus. Congenital anonychia and white café au lait-like spots on the skin of hands and feet are also associated. UMLS:C0796063 MONDO:0009622 MEDGEN:810673 OMIM:251255 microcephaly with intellectual disability and digital anomalies microcephaly with mental retardation and digital anomalies Jawad syndrome multiple congenital anomalies/dysmorphic syndrome-intellectual disability