syndromic disease skin disorder Parana hard-skin syndrome https://www.malacards.org/card/parana_hard_skin_syndrome Orphanet:2812 OMIM:260530 hard-skin syndrome, Parana type GARD:0002598 MONDO:0009838 Parana hard skin syndrome NCIT:C126559 Parana hard-skin syndrome hard skin syndrome, Parana type A rare disorder characterized by rigid, thick skin that covers the entire body and affects movements. The movement of the chest and abdomen is severely restricted. Affected individuals develop respiratory insufficiency which may lead to death. hard skin syndrome Parana type MEDGEN:337964 MESH:C564905 UMLS:C1850079