has material basis in germline mutation in SERPINF2 coagulation protein disease hemorrhagic disease alpha-2-plasmin inhibitor deficiency https://www.malacards.org/card/alpha_2_plasmin_inhibitor_deficiency alpha-2-plasmin inhibitor deficiency plasmin inhibitor deficiency NANDO:2200687 DOID:0060601 SCTID:716746003 MEDGEN:414178 Orphanet:79 UMLS:C2752081 OMIM:262850 antiplasmin deficiency, congenital anti-plasmin deficiency, congenital MONDO:0009883 Congenital alpha2 antiplasmin deficiency is a rare hemorrhagic disorder caused by congenital deficiency of alpha2 antiplasmin, leading to dysregulated fibrinolysis and is characterized by a hemorrhagic tendency presenting from childhood with prolonged bleeding and ecchymoses following minor trauma and spontaneous bleeding episodes (often in unusual locations like diaphysis of long bones). Congenital alpha2 antiplasmin deficiency is inherited in an autosomal recessive manner. GARD:0000731 icd11.foundation:688627594 MESH:C537777 inherited blood coagulation disorder