has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of HSD17B3 testosterone dehydrogenase (NADP+) activity hereditary disease 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency https://github.com/monarch-initiative/mondo/issues/6753 https://www.malacards.org/card/17_beta_hydroxysteroid_dehydrogenase_iii_deficiency 17-beta-hydroxysteroid dehydrogenase 3 deficiency MONDO:0009916 NCIT:C120203 neutral 17-Beta-hydroxysteroid oxidoreductase deficiency 17 alpha KSR deficiency DOID:0112248 OMIM:264300 UMLS:C0268296 polycystic ovarian disease due to 17-ketosteroid reductase deficiency neutral 17 beta hydroxysteroid oxidoreductase deficiency 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency 17-Beta hydroxysteroid dehydrogenase 3 deficiency NANDO:2200390 17-KSR deficiency Male pseudoherma-phroditism with gynecomastia icd11.foundation:887793448 17-beta hydroxysteroid dehydrogenase 3 deficiency GARD:0005659 17 Beta HSD3 deficiency 17-ketosteroid reductase deficiency of testis Orphanet:752 17-BETA hydroxysteroid dehydrogenase III deficiency Decreased activity of the steroidogenic enzyme, 17-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD17B3 gene, leading to reduced testosterone production. polycystic ovary syndrome due to 17-ketosteroid reductase deficiency pseudohermaphroditism, Male, with gynecomastia 17 beta hydroxysteroid dehydrogenase III deficiency MEDGEN:120626 17 beta HSD3 deficiency MESH:C564868 17-ketosteroidreductase deficiency Male pseudohermaphroditism due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency MESH:C537805 17 alpha ketosteroid reductase deficiency of testis SCTID:50658006 17-ketoreductase deficiency 46,XY disorder of sex development