has material basis in germline mutation in IGF1R hereditary disease growth delay due to insulin-like growth factor I resistance https://rarediseases.info.nih.gov/diseases/10609/insulin-like-growth-factor-1-resistance-to https://www.malacards.org/card/growth_delay_due_to_insulin_like_growth_factor_i_resistance https://www.malacards.org/card/insulin_like_growth_factor_i MESH:C564816 icd11.foundation:272435490 MEDGEN:338622 UMLS:C1849157 Somatomedin, end-organ insensitivity to Somatomedin-c resistance to insulin-like Growth Factor I, resistance to, due to increased binding Protein Growth delay due to IGF-I resistance is characterized by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels. Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum). IGF1RES Orphanet:73273 NANDO:2200320 MONDO:0010038 growth delay due to insulin-like growth factor I resistance OMIM:270450 IGF-I resistance resistance to IGF-1 SCTID:715625007 GARD:0010609 Somatomedin end-organ insensitivity to IGF-1 resistance Somatomedin-C, resistance to insulin-like growth factor 1 resistance to insulin-like growth factor I, resistance to growth hormone insensitivity syndrome