has material basis in germline mutation in ZFYVE26 hereditary spastic paraplegia 15 https://github.com/monarch-initiative/mondo/issues/6878 https://www.malacards.org/card/spastic_paraplegia_15_autosomal_recessive Autosomal recessive spastic paraplegia type 15 is a complex form of hereditary spastic paraplegia characterized by a childhood to adulthood onset of slowly progressive lower limb spasticity (resulting in gait disturbance, extensor plantar responses and decreased vibration sense) associated with mild intellectual disability, mild cerebellar ataxia, peripheral neuropathy (with distal upper limb amyotrophy) and retinal degeneration. Thin corpus callosum is a common imaging finding. recessive spastic paraplegia with retinal degeneration OMIM:270700 Orphanet:100996 DOID:0110768 spastic paraplegia 15, autosomal recessive ZFYVE26 autosomal recessive complex spastic paraplegia hereditary spastic paraparesis type 15 spastic paraplegia 15 spastic paraplegia and retinal degeneration MONDO:0010044 autosomal recessive complex spastic paraplegia caused by mutation in ZFYVE26 UMLS:C1849128 spastic paraplegia-retinal degeneration syndrome GARD:0009581 hereditary spastic paraplegia 15 SCTID:709417000 hereditary spastic paraplegia type 15 autosomal recessive spastic paraplegia type 15 Kjellin syndrome SPG15 MESH:C536642 MEDGEN:341387 complex hereditary spastic paraplegia