has material basis in germline mutation in MLH1 mismatch repair cancer syndrome 1 https://github.com/monarch-initiative/mondo/issues/6752 https://github.com/monarch-initiative/mondo/issues/7068 https://github.com/monarch-initiative/mondo/issues/9178 https://github.com/monarch-initiative/mondo/issues/9285 https://www.malacards.org/card/mismatch_repair_cancer_syndrome_1 UMLS:C5399763 MONDO:0010159 glioma-polyposis syndrome SCTID:61665008 MLH1-related constitutional mismatch repair deficiency syndrome MESH:C536928 An autosomal recessive constitutional mismatch repair deficiency syndrome caused by pathogenic variants in the MLH1 mismatch repair gene. It is characterized by a high risk of childhood cancers, including hematological malignancies and brain tumors, as well as colorectal cancers with polyposis. brain tumor-polyposis syndrome MEDGEN:1748029 OMIM:276300 GARD:0000420 MMRCS1 CNS tumors with familial polyposis of the colon NORD:1805 mismatch repair cancer syndrome CNS tumours with familial polyposis of the colon Turcot Syndrome brain tumor-polyposis syndrome 1 mismatch repair cancer syndrome 1 BTP1 syndrome malignant tumours of the central nervous system associated with familial polyposis of the colon MMRCS malignant tumors of the central nervous system associated with familial polyposis of the colon hereditary neoplastic syndrome mismatch repair cancer syndrome hereditary neurological disease