has material basis in germline mutation in VWF von Willebrand disease 3 https://www.malacards.org/card/von_willebrand_disease_type_3 MESH:D056729 VWD, type 3 SCTID:128108002 MONDO:0010191 von Willebrand's disease type 3 von Willebrand disease 3 von Willebrand disease type 3 Von Willebrand disease, type 3 VON WILLEBRAND disease, type 3 Type 3 von Willebrand disease (type 3 VWD) is the most severe form of VWD characterized by a bleeding disorder associated with a total or near-total absence of Willebrand factor (von Willebrand factor; VWF) in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII (FVIII). OMIM:277480 MEDGEN:266075 von Willebrand's disease 3 GARD:0017025 Orphanet:166096 VWD3 NCIT:C85213 DOID:0111054 UMLS:C1264041 hereditary von Willebrand disease